منابع مشابه
microRNA-induced IgA nephropathy.
IgA nephropathy (IgAN) is the most common GN in the world. Prevalence of IgAN is extremely high, noted in 30%– 40% of renal biopsies in Asian countries and South Europe. In Japan, the Renal Biopsy Registry compiles information from .1500 cases a year, among which the most frequent pathologic diagnosis is IgAN at 30%. Glomerular IgA deposition is observed in 16% of zero-hour biopsies, and IgA ne...
متن کاملPotential serum microRNA signatures of pediatric IgA nephropathy
IgA nephropathy (IgAN) is one of the most common causes leading to end-stage renal failure. The regulatory mechanisms underlying the emergence of microRNA are poorly understood and need to be studied for developing better strategies for diagnosis and treatment of pediatric IgA nephropathy. We performed a microRNA sequence analysis of the plasma microRNAs of pediatric patients with IgA nephropat...
متن کاملExperimental IgA nephropathy induced by oral immunization
To test the hypothesis that IgA nephropathy can result from a mucosal immune response, mice were orally immunized with one of three protein antigens for 14 wk. Such mice exhibited an essentially pure mucosal antibody response characterized by specific IgA-producing plasma cells in exocrine sites and specific IgA antibodies in serum. Furthermore, 73% of immunized mice had IgA and 88% had immunog...
متن کاملIgA nephropathy.
A great interest in IgA nephropathy was demonstrated in the last few years. Unfortunately, a complete picture of this chronic disease should not yet been made. The article deals with 7 patients with IgA nephropathy treated in our Institute. The following characteristics were examined during a long period of time (1-17 years): clinical picture, course of the disease, clinical and morphologic cor...
متن کامل[IgA nephropathy].
IgA nephropathy is glomerular disease first described in 1968 by Berger, named after him Morbus Berger. The disease is characterized by the presence of IgA dominant or codominant immunoglobulin deposits in glomerular mesangium which can be demonstrated by immunofluorescence. Clinical manifestations of IgA nephropathy in the majority of cases is hematuria which can be macro or microscopic, isola...
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ژورنال
عنوان ژورنال: Journal of the American Society of Nephrology
سال: 2012
ISSN: 1046-6673,1533-3450
DOI: 10.1681/asn.2012030249